Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA.
نویسندگان
چکیده
Subcutaneous vaccination with recombinant antigen 2/PRA (rAg2/PRA) protected BALB/c mice against intranasal infection with Coccidioides immitis. Subcutaneously vaccinated C57BL/6 mice and intranasally vaccinated BALB/c mice were protected against larger numbers of infecting spores. Weight loss correlated with lethality, but histologic appearance did not. These studies support rAg2/PRA vaccination to prevent coccidioidomycosis.
منابع مشابه
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ورودعنوان ژورنال:
- Infection and immunity
دوره 70 6 شماره
صفحات -
تاریخ انتشار 2002